有多列表是否有任何缺点

I'm planning a database structure which is going to store quite a bit of data. We need to store 50 different 'columns' of data for each item. Adding a timestamp, that gives us 52 columns (and 2 indexes which will be the only way this data is going to be filtered). This database will get a few thousand rows added every day (and never updated), and will be in use for a while.I'm planning a database structure which is goin