多个脚本/配置文件的文本替换

I am doing some sort of science with a combination of Python, bash scripts and configuration files with weird syntaxes from old C programs. To run different tests, I have to tune (open text file, edit and save) a number of these files, but it is getting harder and harder to remember which files to edit. Also, the tasks are very repetitive and I end having a bunch of comment lines, switching on and off the settings for a specific run.I am doing some sort of science with a combinat