Assume we have two different asp.net solutions solutionA_32bit and solutionB_64bit. As the names suggest, solutionA needs to be run in 32bit mode (aka within a 32bit iis-express) and solutionB needs to be run in 64bit mode (aka within a 64bit iis-express). The only option I've seen so far in order to make these solutions run is to tweak a global option in visual studio which can be found underAssume we have two different asp.net solutions