在css中实现以下设计

I am trying to make the following design for a web site. The last time I made a web site, everything was usually done using a bunch of tables to align the element on the page. I can understand that this is not how we roll in 2011, where it's all about the css. I have tried to implement the following design using css, but I have not succeeded. Can someone point me in the right direction?I am trying to make the following design for a