我应该使用一些Javascript MVVM框架还是使用旧式的构建应用程序的方式？

I know Knockout.JS and Angular.JS at the intermediate's level. It is great for building Single Page applications. However, my new project is going to be very large and would last almost 3 years building it (approximately 50 pages). I am pretty sure Single Page application concept is not going to fit here due to the complexity of the project and large number of pages that have varied functionality. at the interm