如何编写一个桌面应用程序，使用HTML和CSS作为用户界面，使用python/perl/c++/java进行处理?

Different languages have different GUI toolkits, but it looks very difficult to achieve attractive user interfaces as good as we can using HTML and CSS with less effort. I don't do my application in javascript as I doubt if it has all the required libraries and I want to do it in python.Different languages have different GUI toolkits